| fmyykjn | Дата: Понедельник, 02.03.2015, 17:21 | Сообщение # 1 |
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Группа: Гости
| Daptomycin is a cyclic lipopeptide antibiotic produced past the being Streptomyces roseosporus.[14 - [15 - Daptomycin consists of thirteen amino acids, ten of which are arranged in a cyclic manner, and three that adorn an exocyclic tail. Two non-proteinogenic amino acids exist in the lipopeptide, the peculiar amino acid L-kynurenine (Kyn), no more than known to Daptomycin, and L-3-methylglutamic acid (mGlu). The N-terminus of the exocyclic tryptophan remainder is coupled to decanoic acid, a approach limit (C10) fatty acid. Biosynthesis is initiated alongside the coupling of decanoic acid to the N-terminal tryptophan, followed beside the coupling of the remaining amino acids past nonribosomal peptide synthetase (NRPS) mechanisms. In the end, a cyclization outcome occurs, which is catalyzed by a thioesterase enzyme, and ensuing disseminate of the lipopeptide is granted.
The non-ribosomal peptide synthetase (NRPS) honest over the extent of the combination of Daptomycin is encoded aside three overlapping genes, dptA, dptBC and dptD. The dptE and dptF genes, immediately upstream of dptA, are indubitably to be knotty in the installation of daptomycin biosynthesis by coupling decanoic acid to the N-terminal Trp.[16 - These tale genes (dptE, dptF ) agree to products that most qualified industry in conjunction with a unique condensation specialization to acylate the original amino acid (tryptophan). These and other novella genes (dptI, dptJ) are believed to be involved in supplying the non-proteinogenic amino acids L-3-methylglutamic acid and Kyn; they are located next to the NRPS genes.[16 -
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